Many breast cancers involve mutations in the BRCA1 gene. Explain the difference between sporadic

and familial breast cancer caused by this gene at a molecular level.



What will be an ideal response?


In order to develop breast cancer from a mutation in the BRCA1 gene, both copies of the gene must be
mutated. In sporadic breast cancer, the cell starts out with two normal copies of the gene, but over
time, a mutation arises in one copy and then the other. In familial cancer, a person inherits one normal
copy of the gene and one mutant copy. Therefore, a cell only needs to acquire a mutation in the one
normal copy of the gene.

Biology & Microbiology

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