A 14-year-old female has been experiencing severe internal cramps in the region of the pelvis and weight loss.She has been admitted with rectal bleeding

Question

The physician has diagnosed her with inflammatory bowel disease (IBD). She asks the nurse what causes this disease. The nurse will base her response knowing that IBD has been linked to
A)
liver involvement in faulty glycogen stores.
B)
endoplasmic reticulum stress in the gastrointestinal system.
C)
oversecretion of insulin from the beta cells in the pancreas.
D)
infiltration of the gastrointestinal tract by bacterial toxins.

Answer 1

Ans:
B

Feedback:

Researchers are determining links between the endoplasmic reticulum (ER) and various disease processes. For examples, ER stress in the GI system has been found to be related to intestinal inflammations such as those occur with inflammatory bowel disease. The smooth ER of the liver is involved in glycogen stores. Insulin is synthesized as a large, inactive proinsulin molecule cut apart to produce a smaller, active insulin molecule within the Golgi complex of the beta cells. Bacterial toxins have exploited the retrograde transport mechanism.