When asked how tricyclic antidepressants affect neurotransmitter activity, the nurse should respond that they:
a. Decrease available dopamine.
b. Increase availability of norepinephrine and serotonin.
c. Make available increased amounts of monoamine oxidase.
d. Increase the effects of the chemical gamma-aminobutyric acid.
ANS: B
Tricyclic antidepressants block neurotransmitter uptake, increasing the amounts of norepi-nephrine and serotonin available. Decreasing dopamine is the action of typical antipsychotic medication. Increasing monoamine oxidase is not the action of tricyclics. Benzodiazepines, not tricyclics, increase the effects of GABA.
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