A client has been hospitalized for a severe urinary tract infection (UTI). Ciprofloxacin IV (Cipro) is prescribed. Two days later, the symptoms have abated, and the client is discharged with a prescription for oral ciprofloxacin (Cipro)
What characteristics of fluoroquinolones allow for this quick discharge from the hospital?
1. Fluoroquinolones given as IV are very expensive, and must be switched to oral administration as soon as possible to save the client money.
2. Fluoroquinolones have equal serum drug levels with either IV or oral administration, which allows for a smooth transition from IV to oral therapy.
3. Fluoroquinolones given as an IV infusion eradicate infection quickly so that the client can be discharged.
4. Fluoroquinolones are less toxic when given orally.
Correct Answer: 2
Global Rationale: The serum levels of oral and IV administration of fluoroquinolones are the same, allowing for a smooth transition from IV to oral therapy. Many drugs are expensive, but this would not be a reason for early discharge from the hospital. Fluoroquinolones are effective against infection, but antibacterials must be given for a course of approximately 10 days. There is no difference in toxicity between IV and PO dosage.
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