Place these pathophysiologic mechanisms of DIC in the order in which they occur
1 . Activation of the fibrinolytic system
2 . Breakdown of thrombi; spontaneous hemorrhage
3 . Consumption of coagulation factors; failure of regulatory mechanisms
4 . Endothelial damage; release of tissue factor
5 . Thrombin formation; clots form along epithelial walls
a. 4, 1, 5, 2, 3
b. 4, 1, 3, 2, 5
c. 5, 1, 2, 4, 3
d. 2, 3, 1, 5, 4
A
Endothelial damage triggers the release of tissue factor. Thrombin is released, and clots form, consuming coagulation factors. The fibrinolytic system is triggered to break down the clots, which leads to spontaneous hemorrhage.
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