A client with breast cancer is scheduled to undergo chemotherapy with aromatase inhibitors. Which of the following best reflects the rationale for using this group of drugs?
A) They lower the level of estrogen in the body blocking the tumor's ability to use it.
B) They block progesterone-dependent tumors from growing.
C) They attach to endogenous protein receptors to slow the growth of cancerous cells.
D) They stimulate the immune system to attack a protein common in many tumors.
A
Feedback:
Aromatase inhibitors lower the level of estrogen in the body thereby interfering with the ability of hormone-sensitive tumors to use estrogen for growth. Antiprogestin drug, such as mifepristone, blocks progesterone-dependent breast cancers. The monoclonal antibody, trastuzumab attaches to protein receptors to slow the growth of cancer cells. A breast cancer vaccine is under investigation in Italy. This vaccine stimulates the immune system to attack a protein called mammaglobin-A, which is found in 80% of breast cancer tumors.
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