Which of the following best describes the half-life of a highly protein-bound drug such as thyroxine (99% protein bound)? The half-life would be
A)
much longer to reduce the concentration of the hormone by one half.
B)
shorter because only a little of the hormone has to be used up to reduce the concentration.
C)
dependent on which drugs were in the blood system holding on to the hormone.
D)
dependent on the liver to carry the hormone to its designated target organ.
Ans:
A
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The half-life of a hormoneâ€"the time it takes for the body to reduce the concentration of the hormone by one halfâ€"is positively correlated with its percentage of protein binding. Thyroxine, which is more than 99% protein bound, has a half-life of 6 days, whereas aldosterone, 15% bound, has a half-life of only 25 minutes.
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