A client has been prescribed amphotericin B (AmBisome). Which side effects will the nurse monitor this client for while receiving this medication?(Select all that apply.)

Question

1. Hepatotoxicity
2. Phlebitis
3. Creatinine
4. Fever and chill
5. Cardiac irregularities

Answer 1

2, 3, 4

Rationale 1:Hepatotoxicity is incorrect because it is not caused by amphotericin B.
Rationale 2: Phlebitis, or inflammation of the veins, is common during IV therapy.
Rationale 3: Some degree of nephrotoxicity is observed in most patients, and laboratory tests of kidney function (creatinine and blood urea nitrogen [BUN]) are normally performed throughout the treatment period.
Rationale 4: Many patients develop fever and chills at the beginning of therapy, which subside as treatment continues. Some degree of nephrotoxicity is observed in most patients, and laboratory tests of kidney function are normally performed throughout the treatment period.
Rationale 5:Cardiac irregularities are not associated with amphotericin B therapy.

Global Rationale: Many patients develop fever and chills at the beginning of therapy, which subside as treatment continues. Some degree of nephrotoxicity is observed in most patients, and laboratory tests of kidney function such as creatinine and blood urea nitrogen (BUN)are normally performed throughout the treatment period. Phlebitis, or inflammation of the veins, is common during IV therapy.