What adverse effect may manifest as dizziness, tinnitus, and progressive hearing loss?
a. Ear infection
b. Drug allergy
c. Ototoxicity
d. Idiosyncratic reaction
ANS: C
Damage to the eighth cranial nerve (ototoxicity) can occur from drug therapy, particularly from aminoglycosides. This may initially be manifested by dizziness, tinnitus, and progressive hearing loss. Ear infection is not an adverse effect of drug therapy. Drug allergy is not manifested by hearing loss. Idiosyncratic reaction to a medication is an unusual, unpredictable response specific to a particular person. Unlike allergy, it can occur on first exposure to the medication; unlike an adverse effect, it only affects very few individuals, possibly with a genetic or metabolic abnormality.
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