Which of the following genetic changes cannot convert a proto-oncogene into an oncogene?
(a) A mutation that introduces a stop codon immediately after the codon for the initiator methionine.
(b) A mutation within the coding sequence that makes the protein hyperactive.
(c) An amplification of the number of copies of the proto-oncogene, causing overproduction of the normal protein.
(d) A mutation in the promoter of the proto-oncogene, causing the normal protein to be transcribed and translated at an abnormally high level.
(a) A mutation that introduces a stop codon immediately after the codon for the initiator methionine will result in no protein being produced. Proto-oncogenes become oncogenes when they acquire mutations that cause them to act in a dominant hyperactive manner [choices (b), (c), and (d)].
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