Please describe the macrophage theory of depression. To what extent is the theory supported empirically?
What will be an ideal response?
Ans: There are similarities to the response of physical sickness and depression. Cytokines acting on the brain produce the experience of sickness, leading to behaviors similar to those seen in depression. This has led to the theory that cytokine malfunction may be involved with depression. At present, the theory enjoys only mixed support; the evidence suggests that depression leads to rather than stems from depressed immune system responses.
Learning Objective: 6.2 Describe the characteristics and causes of major depressive disorder.
Cognitive Domain: Analysis
Answer Location: Are Depression and Inflammation Related?
Difficulty Level: Medium
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