Do the factors affecting affinity of hemoglobin for oxygen have the same impact on loading and unloading in lungs and tissues? Explain your answer, and indicate if this presents a conflict in remedying hypoxia. Assuming a medical team has treatments available for changing all the factors affecting hemoglobin's oxygen affinity, how should they manipulate pH, temperature, PCO2, and 2,3-DPG content
in a hypoxic patient?
What will be an ideal response?
Hemoglobin affinity changes in the same way in the lungs and tissues, thus increasing unloading in the tissues does decrease loading in the lungs, which seems as if one cancels out the other. But from the oxygen dissociation curves it is evident that the impact is greater in the tissues; thus increased unloading can remedy hypoxia. The medical team should decrease pH, increase temperature, increase PCO2, and increase 2,3-DPG.
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