In which stage of wound healing does angiogenesis occur?

Question

1. Proliferation
2. Inflammation
3. Remodeling
4. Maturation

Answer 1

Proliferation

Rationale: During proliferation, growth factors originating from injured vessels stimulate the formation of vascular buds and regrowth of vascular loops. Stimulated endothelial cells multiply and form tubular structures differentiating into arterioles or venules, a process referred to as angiogenesis. When injury to the epidermis, dermis, and subcutaneous tissue occurs, the inflammatory phase of wound healing begins. Within hours after injury, histamines are released from mast cells, causing local vasodilation and increased capillary permeability. This allows leakage of serous fluid into the injured site, which results in erythema, edema, and the production of exudates. The third and final phase of wound healing is maturation or remodeling, which are synonymous terms. This phase begins after the wound is closed. During this phase the scar changes and matures. The bulk decreases and the color changes from pink to pearly white.