Zidovudine (Retrovir) has been prescribed to a client with HIV. The client asks why it is given in combination with other medications to treat HIV. What should the nurse include in the teaching session for this client?(Select all that apply.)
1. The combination will cure HIV.
2. The combination allows HIV to be attacked by several different mechanisms.
3. Strains of HIV resistant to zidovudine are common.
4. The combination slows the development of resistance.
5. The combination is more cost effective.
2, 3, 4
Rationale 1:There is no cure for HIV.
Rationale 2: Because of its widespread use over the past 25 years, strains of HIV resistant to zidovudine are common. It is usually used in combination with other antiretrovirals because this slows the development of resistance and allows HIV to be attacked by several different mechanisms.
Rationale 3: Because of its widespread use over the past 25 years, strains of HIV resistant to zidovudine are common. It is usually used in combination with other antiretrovirals because this slows the development of resistance and allows HIV to be attacked by several different mechanisms.
Rationale 4: Because of its widespread use over the past 25 years, strains of HIV resistant to zidovudine are common. It is usually used in combination with other antiretrovirals because this slows the development of resistance and allows HIV to be attacked by several different mechanisms.
Rationale 5:Medications used to treat HIV are quite costly. The combination is not prescribed for cost effectiveness.
Global Rationale: Because of its widespread use over the past 25 years, strains of HIV resistant to zidovudine are common. It is usually used in combination with other antiretrovirals because this slows the development of resistance and allows HIV to be attacked by several different mechanisms.
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