Why is the formation of a BCR-ABL fusion gene a carcinogenic event?
A. The tyrosine kinase activity of the ABL gene becomes inactive.
B. The tyrosine kinase activity of the ABL gene is now controlled by a weak promoter resulting in less tyrosine kinase activity.
C. The tyrosine kinase activity of the ABL gene becomes unregulated leading to uncontrollable cell division.
D. The tyrosine kinase activity of the ABL gene is reduced due to truncation of the protein product.
E. The tyrosine kinase activity of the BCR gene is increased in the fusion protein product.
C
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Answer the following statements true (T) or false (F)
1. Bacterial capsules protect bacteria from being phagocytized by leukocytes. 2. A headache is a classic example of a sign of a disease. 3. To cause disease, all bacterial pathogens must first attach to some tissue in the body. 4. Rickettsias and chlamydias are examples of obligate intracellular pathogens. 5. Babesia spp., Ehrlichia spp., and Plasmodium spp. are examples of intraerythrocytic pathogens.
Which of the following statements is true regarding factors associated with the immortalization of cancer cells?
A) inhibition of growth B) stimulation of apoptosis C) telomerase activity D) tumor-suppressor activation E) both choices B and D
Comparison of mitosis and cytokinesis in animal versus plant cells reveals ____
a. sister chromatids are identical in animal cells, but they differ from one another in plants b. a cleavage furrow is initiated in an animal cell, while a cell plate begins to form in plant cells during telophase c. in animal cells, chromosomes do not become attached to the spindle until anaphase, whereas chromosomes become attached to the spindle at prophase in plant cells d. the nuclear envelope disintegrates in prophase in animal cells, but remains intact in plant cells e. There are no differences between animal and plant cells.
Inside a skeletal muscle cell, a set of small cylinders called _______ are assembled into larger cylinders called _______.
Fill in the blank(s) with the appropriate word(s).