Discuss the possible reasons for exercise-induced arterial hypoxemia


The high cardiac output of endurance-trained athletes can cause a mismatch between perfusion and diffusion produced by high pulmonary blood.

In some individuals, the presence of subclinical hyperactive airways results in mild airway constriction and a reduction of the flow-volume envelope. The mild airway constriction impairs gas exchange, resulting in EIAH.

Some individuals have small intracardiac or intrapulmonary shunts (where venous blood bypasses the alveoli and, therefore, the arterial blood is not fully saturated with oxygen), which cause a widening of the alveolar-arterial oxygen pressure difference, resulting in EIAH.

Fatigue of the respiratory muscles may cause limitations in performance, especially during prolonged exercise at 80 to 85 percent VO2 max, when the work of breathing becomes so strenuous that the diaphragm has been shown to fatigue and limit exercise performance.

Health & Biomechanics

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