Antibodies are Y-shaped molecules that have two identical binding sites. Suppose that you have obtained an antibody that is specific for the extracellular domain of an RTK. When the antibody binds to the RTK, it brings together two RTK molecules
If cells containing the RTK were exposed to the antibody, would you expect the kinase to be activated, inactivated, or unaffected? Explain your reasoning.
The RTK will probably become activated on binding of the antibody molecule. This is because signal-induced dimerization usually activates RTKs. When RTK molecules are brought together, their cytoplasmic kinase domains become activated and each receptor phosphorylates the other.
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Which of the following is not a step in nonhomologous end joining?
A. phosphorylation of the Ku70-Ku80 complex B. degradation of any single-strand overhangs or hairpins from the broken ends of the chromosomes to be repaired C. binding of the Ku70-Ku80 complex to the broken chromosome ends D. binding of a kinase and a nuclease to the Ku70-Ku80 complex on the DNA E. All of the steps given occur in NHEJ.
The delicate nature of kelp beds is a result of the slow growth rates of kelps
Indicate whether the statement is true or false
Goblet cells are located in columnar epithelium and secrete mucus.
a. true b. false
Denaturation disrupts the secondary and tertiary structure of proteins. However, denaturation is not strong enough to disrupt what interaction that is relevant to protein structure?
A. van der Waals attraction B. hydrophobic exclusion C. hydrogen bonds D. peptide bonds E. ionic bonds