What drug interactions in the liver are of primary importance? Select all that apply
1. Excretion
2. Dependence
3. Induction
4. Inhibition
5. Tolerance
Answer: 3, 4
Explanation: Two interactions that occur when one substance competes with another at sites of enzymatic activity are of particular importance: induction and inhibition. The inhibitive competition of one substance interferes with the ability of the enzyme to breakdown the other substance, while induction hastens the speed of enzymatic action. Excretion is a pharmokinetic process that is not necessarily associated with drug interactions. Dependence refers to a developed compulsive need to use a substance to function normally. Tolerance results when the presentation of a medication to a receptor leads to a diminished effect of the drug over time.
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