Which of the following statements below is the best explanation of why MyoD can cause fibroblasts to express muscle-specific genes?
(a) Unlike some other cell types, fibroblasts have not lost the muscle-specific genes from their genome
(b) The muscle-specific genes must be in heterochromatin in fibroblasts
(c) During their developmental history, fibroblasts have accumulated some transcriptional regulators in common with differentiating muscle cells
(d) The presence of MyoD is sufficient to activate the transcription of muscle-specific genes in all cell types
Answer: (c) During their developmental history, fibroblasts have accumulated some transcriptional regulators in common with differentiating muscle cells
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