Some patients with defective mitochondria in their muscles are extremely limited in their ability to exercise
Muscle biopsy followed by microscopic examination of the mitochondria,
reveal that they are of normal size, but their inner membranes are not as convoluted as
normal mitochondria. How can this mitochondrial defect cause the described symptoms in
the patients?
A. It can't. There must be something wrong
with something else in the muscle cells.
B. A less convoluted membrane is more
permeable, so ATP cannot be synthesized
efficiently.
C. A less convoluted membrane has less
surface area, so there is not as much of the
ATP-making machinery.
D. The less convoluted inner membrane
causes the two membranes of a
mitochondrion to adhere together, decreasing
the mitochondrial effectiveness.
E. There is not enough information to
determine the cause.
Answer Key: C
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