The topoisomerase DNA gyrase will introduce negative supercoils into DNA. What effect will this enzyme have on relaxed, covalently closed DNA?
A. The linking number will increase.
B. The DNA will become overwound.
C. The treated DNA will migrate farther in an agarose gel than the relaxed DNA.
D. The linking number will become undefined.
E. The relaxed DNA will migrate farther in an agarose gel than the treated DNA.
C
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