How does the loop of Henle enable the mammalian kidney to produce hypertonic urine?IThe ascending limb of the loop actively extrudes Na+.IIThe descending limb interacts with the ascending limb to raise the osmolarity of the extracellular fluid in the renal medulla.IIIThe concentration is further enhanced by the presence of urea, which draws water out of the collecting ducts by osmosis.
A. Just III
B. II and III
C. Just I
D. I, II, and III
E. I and II
Answer: D
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