A platelet aggregation study shows diminished response to all agonists except for a small response to arachidonic acid and full response to ristocetin. Which condition is most likely?
a. Glanzmann thrombasthenia
b. Aspirin use
c. VWD
d. Platelet release defect
ANS: A
Glanzmann thrombasthenia is diagnosed by its diminished secretion and aggregation responses to all agonists except a modest response to arachidonic acid and full, although nondiagnostic, response to ristocetin.
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