You are assembling a model of a chromosome, but begin having some trouble when you get to the step of forming chromatin loops. If you are unable to resolve this problem, what step of chromosome structure would you be unable to achieve?
A. Histone/DNA complex
B. Nucleosome
C. Solenoid
D. Rosettes
Clarify Question
· What is the key concept addressed by the question?
· What type of thinking is required?
· What key words does the question contain and what do they mean?
Gather Content
· What do you know about chromosome structure? How does it relate to the question?
Consider Possibilities
· What other information is related to the question? Which information is most useful?
Choose Answer
· Given what you now know, what information and/or problem solving approach is most likely to produce the correct answer?
Reflect on Process
· Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
D. Rosettes
Clarify Question
· What is the key concept addressed by the question?
o The question asks about the organization of chromosomes.
· What type of thinking is required?
o You are being asked to apply your knowledge of chromosomes to predict what would happen if chromatin loops could not form.
· What key words does the question contain and what do they mean?
Gather Content
· What do you know about chromosome structure? How does it relate to the question?
o A chromatin loop forms from a solenoid and several of these loops then form a rosette.
Consider Possibilities
· What other information is related to the question? Which information is most useful?
o Histone/DNA complexes could coil tightly to form a nucleosome and these in turn coil tightly to form a solenoid, so all of these structures could still form even if the chromatin loop could not.
Choose Answer
· Given what you now know, what information and/or problem solving approach is most likely to produce the correct answer?
o If a chromatin loop cannot form, then the next higher order structure formed from the chromatin loop cannot form. In this case the rosettes cannot form.
Reflect on Process
· Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
o This question asked you to apply your understanding of chromosome organization to predict what would happen if chromatin loops could not form. If you got the correct answer, great job! If you got an incorrect answer, where did the process break down? Did you recall the order of the structures from smallest to largest is DNA/histone complex, nucleosome, solenoid, chromatin loop, rosette? Did you understand that if the step of chromatin loop was blocked, the next step would be blocked so no rosettes would form?
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