When comparing the enhanced effectiveness of clozapine with the "classical" first-generation antipsychotic medications, the wider range of action produced by clozapine may be because it:
a. is extremely potent at dopamine-2 receptors without causing side effects at other sites
b. does not have an affinity for dopamine receptors
c. affects dopamine receptors 1 and 4 as well as several other neurotransmitter systems
d. is long-acting over several weeks following a single injection
C
Clozapine's wider range of action may be the result of the medication's effects on dopamine receptors D1 and D4 and several other transmitters. In addition, clozapine blocks dopamine receptor D2, which all other antipsychotics block as well. Illnesses such as schizophrenia (and perhaps other psychoses) involve excessive activation of dopamine receptor D2, and antipsychotics seek to alleviate the illness by blocking such activation.
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