Describe this process and its consequences
What will be an ideal response?
In somatic hypermutation, which occurs only in activated B cells, random point mutations are introduced into the rearranged V regions of H-chain and L-chain genes at a rate six orders of magnitude higher than spontaneous mutation. Some of these mutations give rise to immunoglobulin with higher affinity for the antigen than the original immunoglobulin. Those B cells producing higher-affinity surface immunoglobulin will be preferentially selected for activation by the antigen and will come to dominate the response, differentiating into plasma cells producing high-affinity antibodies.
You might also like to view...
When Kristen began to smoke, she only had 3-5 cigarettes. Now, for her to feel in control during the day, she has to smoke 18 cigarettes. What is she experiencing?
A. substance abuse B. substance dependence C. tolerance D. withdrawal
As you start your diet plan, pay particular attention to
a. carbohydrate types. b. fat types and amount. c. food serving sizes. d. nutritional value.
Parker is instructed to drink lots of fluids while taking colchicine for an acute gout attack. Why?
A) To increase production of uric acid B) To prevent dehydration C) To facilitate excretion of uric acid crystals D) To aid in the metabolism of the colchicine
Cellular adaptation to environmental stress (i.e., hot environment) is called
A. homeostatic conversion. B. acclimation. C. adaptation. D. accommodation.