The organism that has been most commonly associated with human disease, particularly in patients who are immunocompromised, such as those infected with human immunodeficiency virus (HIV), is:
a. Rhodococcus.
b. Gordonia.
c. Tsukamurella.
d. Streptomyces.
A
Rhodococcus equi has been the organism most commonly associated with human disease, partic-ularly in patients who are immunocompromised, such as those infected with HIV. R. equi is a facultative intracellular organism that can persist and replicate within macrophages. Determinants of virulence of R. equi are under investigation and may involve cell wall mycolic acids that play a role in intracellular survival, production of interleukin 4, and granuloma formation.
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