Which of the following describes biochemical changes that occur in the intervertebral disc with aging?
a. Increased proteoglycan concentration in the nucleus pulposus
b. Increased water-binding capacity
c. Increased collagen content in nucleus pulposus
d. Increased elastin content in the anulus fibrosis
ANS: C
During maturation and aging, there is a change in the type and amount of collagen content in the
nucleus pulposus. The total amount of collagen increases steadily from about 6% to 25% of the dry
weight of the center of the nucleus pulposus to 70% in the outer anulus.
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