A genetic variation in how the metabolite of the cancer drug irinotecan SN-38 is inactivated by the body may lead to:
1. Decreased effectiveness of irinotecan in the treatment of cancer
2. Increased adverse drug reactions, such as neutropenia
3. Delayed metabolism of the prodrug irinotecan into the active metabolite SN-38
4. Increased concerns for irinotecan being carcinogenic
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A 22-year-old male exercises by swimming laps. Which organ secretes enzymes responsible for the digestion of carbohydrates to provide energy?
A) Liver B) Gallbladder C) Pancreas D) Small intestine
A client tells the nurse about knowing when a vitamin B12 injection is due because there is an increase in tingling of the fingers and toes. What does this information provide to the nurse?
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According to the American Academy of Pediatrics, the use of fluoride supplements to babies whose home drinking water does not contain at least 0.3 parts per million (ppm) concentration should begin at which of the following ages?
a. 3 months c. 1 year b. 6 months d. 2 years
C.Q. returns to the clinic two days later. The physician informs you that C.Q.'s Western blot test results confirm that she is HIV positive; he requests that you be present when he talks to her. Before leaving C.Q.'room, the physician requests that you give C.Q. verbal and written information about local HIV support groups and help C.Q. call a friend to accompany her home this evening. She looks at you through her tears and states, "I can't believe it. J. is the only man I've had sex with since my divorce. He told me I had nothing to worry about. I can't believe he would do this to me."
C.Q.'s statement is based on three assumptions: (1) J. is HIV positive; (2) he intentionally withheld the information from her; and (3) he intentionally transmitted the HIV to her through unprotected sex. Based on your knowledge of HIV infection, how would you counsel C.Q.?