What are some problems associated with glucocorticoid use?
What will be an ideal response?
Glucocorticoids can affect the following body systems:
Glucocorticoids can delay wound healing because they can inhibit fibroblasts, which are involved in wound healing. Because they inhibit wound healing, glucocorticoids can also minimize scar formation.
Glucocorticoids suppress the immune system, which may make infections worse. Bacteria, viruses, fungi, and parasites can replicate unchecked if the immune response is delayed with glucocorticoid use.
Vaccination protocols may be affected during their use. Glucocorticoids do not significantly reduce antibody formation when
they suppress the immune response. Some manufacturers of modified-live vaccines do not recommend vaccinating animals while they are receiving glucocorticoids because of the potential for the virus to replicate in the animal.
Glucocorticoids inhibit prostaglandin production in the stomach. Prostaglandins help protect the gastric mucosa from hydrochloric acid produced in the stomach. Glucocorticoids may also increase gastric acid production, making ulcer formation more likely during their use.
Glucocorticoids applied to an eye with a corneal defect or injury can cause the ulcer to worsen.
Glucocorticoids may induce labor if given in near-term pregnant females.
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