What is the mechanism for the platelet dysfunction in multiple myeloma and Waldenström
a. Granules become deficient.
b. Platelets are coated with paraprotein.
c. Nitric oxide is not produced.
d. Cyclooxygenase is acetylated.
ANS: B
In both of these disorders, a high concentration of a monoclonal protein is present in circulation. This is called a paraprotein, and it can coat platelets, interfering with surface receptors, leading to their dysfunction.
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