Depletion of serum haptoglobin indicates:

a. Decreased erythropoiesis
b. Extravascular hemolysis
c. Intravascular hemolysis
d. Increased phagocytosis of macrophages


ANS: C
Haptoglobin is a plasma protein that binds any free hemoglobin in plasma after red cells lysis in circulation. This helps salvage the iron in the hemoglobin so that it is not lost. When significant intravascular hemolysis (lysis in the blood) exists, haptoglobin is depleted; this can be measured in plasma.

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