The ? chain of adult hemoglobin is composed of 146 amino acids of a known sequence. In comparing the normal ? chain with the ? chain in sickle-cell hemoglobin, what alteration is one likely to find?
A) trinucleotide repeats
B) glutamic acid replacing valine in the first position
C) frameshift substitutions
D) extensive amino acid substitutions
E) valine instead of glutamic acid in the sixth position
Answer: E
Biology & Microbiology
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