Which two organs are the major storage sites for iron in a normal individual?
a. Lymph nodes and muscle
b. Bone marrow and pancreas
c. Spleen and heart
d. Liver and spleen
ANS: D
The liver and spleen have a large amount of L (light) subunits of apoferritin, the protein that stores iron; they thus are major storage sites for iron. The L subunits more readily take up iron for storage than the H (heavy) subunits, which are more predominant in tissues where iron is not normally stored such as the heart.
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