Assaying bacterial isolates for resistance genes by molecular methods:
a. can detect unknown resistance genes not yet defined.
b. cannot detect phenotypic resistance due to a combination of mechanisms.
c. means the resistance gene is expressed if found to be present.
d. is currently part of the routine clinical mi-crobiology workflow for all isolates.
B
Molecular methods for resistance genes can only detect those resistance genes that have been characterized and identified, it does not detect novel resistance genes. Also, just because a resis-tance gene is present in the bacteria it does not mean that it is expressed. Moreover, if resistance is manifested due to a number of different mechanisms (e.g., decreased uptake and altered anti-microbial target) and not a single mechanism associated with a single gene, that resistance would be missed.
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