What is the mechanism of action of propylthiouracil?
a. Blocks reuptake of thyroid hormone in the liver
b. Destroys hormone in the thyroid gland
c. Increases synthesis of hormone in the thyroid gland
d. Blocks synthesis of hormone in the thyroid gland
ANS: D
Propylthiouracil and methimazole are antithyroid agents that act by blocking the synthesis of T3 and T4 in the thyroid gland. They do not destroy any T3 or T4 already produced, so there is usually a latent period of a few days to 3 weeks before symptoms improve once therapy is started. Antithyroid medications do not block reuptake of hormones, destroy hormones, or increase synthesis of hormone.
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