A child with cystic fibrosis is receiving recombinant human deoxyribonuclease (rhDNase). This drug:
a. May cause mucus to thicken.
b. May cause voice alterations.
c. Is given subcutaneously.
d. Is not indicated for children younger than 12 years.
ANS: B
Two of the only adverse effects of rhDNase are voice alterations and laryngitis. rhDNase decreases viscosity of mucus, is given in an aerosolized form, and is safe for children younger than 12 years of age.
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