Which of the following operations will NOT increase the industrial lysine production?
A) using a bacterial strain in which aspartokinase does not bind to S-aminoethylcysteine (AEC), an aspartokinase inhibitor.
B) increasing the concentration of S-aminoethylcysteine (AEC), an aspartokinase inhibitor, in the fermentor.
C) fermenting with a bacterial strain that contains mutations in the allosteric site of aspartokinase.
D) increasing the precursor (aspartate) concentration.
E) growing the lysine producing bacterium in a chemostat with constant removal of lysine
Ans: B) increasing the concentration of S-aminoethylcysteine (AEC), an aspartokinase inhibitor, in the fermentor.
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