Consider three different enzymes (identified as 1-3, below), each of which has a unique complement of three amino acids that are crucial for the binding of the substrate at the active site
Select from choices A-D the characteristic you would predict a substrate would possess
that would bind to an active site where these amino acids are present. (Consult Figure 4.2 in
Chapter 4 to help you make your predictions.)
Enzyme 1: leucine, tryptophan, and alanine
A. relatively hydrophobic
B. hydrophilic, with a negative charge
C. hydrophilic, with a positive charge
D. hydrophilic, but without a charge
Answer Key: A
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