In the article “Assessment of Dermatopharmacokinetic Approach in the Bioequivalence Determination of Topical Tretinoin Gel Products” , measurements of the concentration of an anti-fungal gel, in ng per square centimeter of skin, were made one hour after application for 49 individuals. Following are the results. The authors claim that these data are well-modeled by a lognormal distribution. Construct an appropriate probability plot, and use it to determine whether the data support this claim

132.44 76.73 258.46 177.46 73.01 130.62 235.63
107.54 75.95 70.37 88.76 104.00 19.07 174.30
82.87 68.73 41.47 120.44 136.52 82.46 67.04
96.92 93.26 72.92 138.15 82.43 245.41 104.68
82.53 122.59 147.12 129.82 54.83 65.82 75.24
135.52 132.21 85.63 135.79 65.98 349.71 77.84
89.19 102.94 166.11 168.76 155.20 44.35 202.51






The plot is a probability plot of the logs of

the data. The points follow a line reasonably

well, with the exception of the smallest value.

The distribution is approximately normal except

perhaps for the left tail, which may be

somewhat longer than that of a normal distribution.

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