The most critical difference between global nucleotide excision repair (NER) and transcription-coupled repair (TCR) is:

A. the initiation step; in NER the XPC protein recognizes the damage but in TCR it is the RNA polymerase that recognizes the damage.
B. the excision step; NER uses UvrC (exinuclease) to nick the DNA but TCR uses the AP endonuclease.
C. the removal step; NER uses UvrD (helicase) to unwind and release the damaged strand but in TCR the damaged strand is degraded by Pol I.
D. the final step; NER uses Pol I and ligase to fill the gap but TCR uses Pol III and ligase.
E. None of the choices given is correct.


A

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