A nurse is caring for a client with a retinoblastoma. What aspect of the cell cycle does the nurse understand to be the cause of this client's condition?

Question

A) This condition occurs during cellular angiogenesis.
B) This condition is a result of TP53 activation, which contributes to apoptosis.
C) This condition developed during the DNA synthesis phase of the cell cycle.
D) The presence of retinoblastoma protein is the cause of this condition.

Answer 1

C) This condition developed during the DNA synthesis phase of the cell cycle.

Explanation: A) Angiogenesis refers to the growth of new blood vessels, and is a mechanism by which cancer can survive in the body, but is not related to the formation of retinoblastomas.
B) The TP53 gene codes for the production of the p53 tumor suppressor protein, which has been called the guardian of the cell cycle, and is not the cause of retinoblastomas.
C) The retinoblastoma protein is formed during the DNA synthesis phase of the cell cycle. The retinoblastoma protein is so named because if both of the alleles of the retinoblastoma gene are mutated, it results in retinoblastoma, a tumor of the retina in the eye.
D) The retinoblastoma protein is formed during the DNA synthesis phase of the cell cycle. The retinoblastoma protein is so named because if both of the alleles of the retinoblastoma gene are mutated, it results in retinoblastoma, a tumor of the retina in the eye.