A client is prescribed medication that can interact with nutrients in the kidney. Which alteration in pharmokinetics is this client at risk for developing?
a. Excretion
b. Metabolism
c. Polypharmacy
d. Bioavailability
a. Excretion
Interactions between drugs and nutrients in the kidney can cause increased excretion or reabsorption of the by-products of metabolism. Alterations in metabolism refer to alterations that occur once after digestion and absorption when substances are in the circulation. Polypharmacy refers to the use of many drugs which can increase the likelihood of drug/nutrient or drug/drug interactions. Alterations in bioavailability refer to changes in the absorption of drugs and nutrients.
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