Which of the following factors can affect drug absorption? Select all that apply
a. Bioavailability
b. Solubility
c. Ionization
d. Absorbing surfaces
e. Drug forms
f. Half-life
g. Routes of administration
ANS: A, B, C, D, E, G
Factors affecting absorption include bioavailability, solubility, ionization, absorbing surfaces, drug forms, and routes of administration. Half-life does not affect drug absorption. Half-life is the time required for serum concentrations to decrease by one half after absorption and distribu-tion are complete. Although half-life is important because it determines the time required to reach steady state and the dosage interval, it is not considered to be one of the factors affecting ab-sorption.
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