A client is receiving the first dose of sargramostim (Leukine). Which assessment findings should the nurse evaluate as indicating a possible serious adverse effect of this drug?

Question

Standard Text: Select all that apply.
1. Increased blood pressure
2. Tachycardia
3. Difficulty breathing
4. Yellowing of the mucous membranes
5. Rash on the palms

Answer 1

Correct Answer: 2,3
Rationale 1: Trapping of granulocytes in the pulmonary circulation may occur, which would result in lowering of the blood pressure.
Rationale 2: Trapping of granulocytes in the pulmonary circulation may occur, which would result in tachycardia.
Rationale 3: Trapping of granulocytes in the pulmonary circulation may occur, which would result in difficulty breathing.
Rationale 4: Jaundice is not an adverse effect of Leukine and would not occur during an infusion.
Rationale 5: Rash on the palms is not an adverse effect of Leukine.
Global Rationale: Trapping of granulocytes in the pulmonary circulation may occur, which would result in tachycardia and difficulty breathing. This client would also experience a decrease in blood pressure not an increase in blood pressure. Jaundice is not an adverse effect of Leukine and would not occur during an infusion. Rash on the palms is not an adverse effect of Leukine.