A patient with advanced prostate cancer will begin treatment with leuprolide (Lupron). The provider has ordered flutamide to be given as adjunct therapy. The patient asks the nurse why both drugs are necessary
The nurse will tell the patient that:
a. flutamide reduces the side effects, such as hot flushes, caused by leuprolide.
b. flutamide suppresses initial tumor flare caused by leuprolide.
c. leuprolide helps to reduce the toxicity of flutamide.
d. the combination of both drugs increases cancer survival.
ANS: B
Flutamide is given with GnRH agonists, such as leuprolide, to prevent tumor flare when GnRH therapy is begun. Flutamide increases hot flushes. Leuprolide does not decrease flutamide toxicity. There is no increase in cancer survival with this combination.
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