The nurse caring for a client with an allergy to cephalosporins would be cautious in implementing an order for an anti-infective agent from which class?
1. Aminoglycosides
2. Fluoroquinolones
3. Sulfonamides
4. Penicillins
Correct Answer: 4
Rationale 1: Aminoglycosides can be safely administered to this client.
Rationale 2: Fluoroquinolones can be safely administered to this client.
Rationale 3: Sulfonamides can be safely administered to this client.
Rationale 4: Five percent to ten percent of clients who are allergic to penicillin also exhibit hypersensitivity to cephalosporins.
Global Rationale: Although sometimes prescribed for patients who are allergic to penicillin, nurses must be aware that 5 percent to percent of the patients who are allergic to penicillin will also exhibit hypersensitivity to cephalosporins. Despite this small incidence of cross-allergy, the cephalosporins offer a reasonable alternative for patients who are unable to take penicillin. Cephalosporins are contraindicated, however, for patients who have experienced anaphylaxis following penicillin exposure.
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