When caring for a cancer client experiencing chemotherapy-induced nausea and vomiting, which of the following drugs work to delay this nausea and vomiting by acting on the CNS to block the activation of the NK-1 receptors? Select all that apply
A) Serotonin (5-hydroxytryamine) antagonists
B) Neurokinin-1 receptor antagonists
C) Promethazine, a neuroleptic medication
D) Compazine, a dopamine (D2) receptor antagonist
Ans: A, B
Feedback:
The recently developed Neurokinin-1 (NK-1) receptor antagonists are used for the treatment of acute and delayed chemotherapy-induced nausea and vomiting. These drugs act centrally to block the activation of the NK-1 receptors in the vomiting center. Serotonin (5-hydroxytryamine) antagonists are involved in the nausea and emesis associated with cancer chemotherapy and radiation. Promethazine is a neuroleptic medication. Compazine, a dopamine (D2) receptor antagonist, depresses vomiting caused by stimulation of the chemoreceptor trigger zone.
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