An appropriately increased RPI greater than 3 is associated with:
a. Iron deficiency anemia
b. Macrocytic megaloblastic anemia
c. Hemolytic anemia
d. Sideroblastic anemia
ANS: C
Only hemolytic anemias have an appropriately increased RPI. The anemia develops not because production is defective but because survival in circulation is significantly shortened. In iron deficiency anemia, insufficient erythropoiesis occurs. In macrocytic megaloblastic and sideroblastic anemias, erythropoiesis is ineffective.
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