What destroys the red cells in paroxysmal nocturnal hemoglobinuria?
a. Macrophages in the bone marrow
b. Antibodies against red cell membrane antigens
c. Increased susceptibility to complement
d. Macrophages in the spleen
ANS: C
Red cells in paroxysmal nocturnal hemoglobinuria are abnormally sensitive to complement, which is activated on their surface and results in premature destruction of the red cells.
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